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Pneumocystis jirovecii pneumonia in patients with acute myeloid leukaemia

Hung Chang1,2,3, Ming-Chung Kuo1,2, Tung-Liang Lin1

  • 1Division of Hematology-Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Internal Medicine Journal
|January 10, 2018
PubMed

Insights

Pneumocystis pneumonia (PJP) is a significant risk for patients with acute myeloid leukemia (AML). Increased awareness and consideration of prophylaxis are recommended for AML patients to improve outcomes.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Oncology

Background:

  • The relationship between Pneumocystis jirovecii pneumonia (PJP) and acute myeloid leukemia (AML) requires further clarification.
  • PJP is an opportunistic infection that can affect immunocompromised individuals.

Purpose of the Study:

  • To investigate the incidence and outcomes of PJP in patients diagnosed with AML.
  • To assess the clinical significance of PJP in the context of AML treatment.

Main Methods:

  • Retrospective analysis of 291 patients with AML.
  • Identification of patients who developed PJP during their AML treatment course.
  • Evaluation of patient demographics, survival rates, and clinical characteristics.

Main Results:

  • PJP developed in 20 out of 291 AML patients (6.8% incidence).
  • The affected patient group included 14 males and 6 females with a median age of 56.
  • A survival rate of 65% was observed, with 13 patients surviving until hospital discharge.

Conclusions:

  • Pneumocystis jirovecii pneumonia is a notable complication in patients with acute myeloid leukemia.
  • Heightened clinical awareness of PJP in AML patients is crucial.
  • Prophylactic strategies for PJP should be considered in the management of acute myeloid leukemia.
Keywords:
Pneumocystis jiroveciacute myeloid leukaemianeutropaeniapneumonia

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