Related Experiment Video

Updated: Feb 15, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.6K

Stenotrophomonas maltophilia: A marker of lung disease severity

Laura Berdah1, Jessica Taytard1, Sophie Leyronnas1

  • 1APHP, Hôpital Trousseau, Cystic Fibrosis Center, Paris, France.

Pediatric Pulmonology
|January 10, 2018
PubMed
Abstract

Insights

Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patients indicates more severe lung disease. While not directly worsening lung function decline, it correlates with increased exacerbations and hospitalizations in CF children.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Cystic Fibrosis Research

Background:

  • Increasing prevalence of Stenotrophomonas maltophilia lung infections in cystic fibrosis (CF) patients.
  • Controversial pathogenicity of S. maltophilia in CF lung disease progression.

Purpose of the Study:

  • To investigate the impact of initial S. maltophilia infection on lung disease progression in pediatric CF patients.
  • To assess clinical outcomes in CF children following S. maltophilia acquisition.

Main Methods:

  • Retrospective case-control study in a pediatric CF center.
  • Matching 23 S. maltophilia-infected CF cases with 23 uninfected CF controls by age, sex, and CFTR mutations.
  • Collecting clinical data for two years pre- and post-infection, including lung function, exacerbations, and antibiotic courses.

Main Results:

  • CF patients with S. maltophilia showed lower lung function and more frequent exacerbations, hospitalizations, and antibiotic courses prior to infection acquisition.
  • Post-infection, lung function decline was similar between groups, but S. maltophilia cases experienced more frequent exacerbations, hospitalizations, and antibiotic courses.

Conclusions:

  • S. maltophilia infection appears to be a marker of CF lung disease severity.
  • Urgent development of international recommendations to reduce S. maltophilia lung infections in CF patients is warranted.
Keywords:
childrencystic fibrosislung functionpulmonary exacerbation Stenotrophomonas maltophilia

More Related Videos

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling05:47

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling

Published on: February 12, 2019

22.1K
Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

9.4K

Related Concept Videos

Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.5K
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.8K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.9K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.5K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
619