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Updated: Feb 15, 2026

Blood Collection from the American Horseshoe Crab, Limulus Polyphemus
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Published on: October 13, 2008

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The Limulus Blood Cell Secretes α2-Macroglobulin When Activated

P B Armstrong, J P Quigley, F R Rickles

    The Biological Bulletin
    |January 10, 2018
    PubMed
    Summary

    Alpha2-macroglobulin, a key protease-binding protein in horseshoe crab plasma, is also found within their blood cells. This protein is released during cell degranulation, playing a role in immune responses.

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