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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

23
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
23
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

22
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
22
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

20
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
20
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

16
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
16
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

20
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
20
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

24
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
24

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Related Experiment Video

Updated: Feb 15, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
09:44

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery

Published on: September 26, 2025

558

Recent Advances in Wearable Transdermal Delivery Systems.

Morteza Amjadi1,2, Sahar Sheykhansari1, Bradley J Nelson2

  • 1Physical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.

Advanced Materials (Deerfield Beach, Fla.)
|January 10, 2018
PubMed
Summary

Wearable transdermal delivery systems offer noninvasive drug administration. This review covers their materials, fabrication, and release mechanisms, highlighting progress and remaining challenges in healthcare applications.

Keywords:
drug carriersmultifunctional wearable devicesstimuli-responsive materialstransdermal deliverywearable medical systems

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Wearable transdermal delivery systems are gaining prominence for noninvasive drug administration.
  • These systems offer convenience and prolonged drug release compared to traditional methods.

Purpose of the Study:

  • To critically review material prospects, fabrication processes, and drug-release mechanisms of wearable transdermal delivery systems.
  • To discuss advancements in multifunctional wearable devices for closed-loop drug delivery.
  • To identify current challenges and future directions in the field.

Main Methods:

  • Comprehensive literature review of existing research on wearable transdermal delivery systems.
  • Analysis of material properties, fabrication techniques, and drug release kinetics.
  • Evaluation of recent developments in smart wearable devices.

Main Results:

  • Significant progress has been made in the development of wearable transdermal delivery technologies.
  • These systems demonstrate impact across various healthcare applications.
  • Key challenges related to long-term stability, user comfort, and regulatory approval persist.

Conclusions:

  • Wearable transdermal delivery systems represent a promising noninvasive therapeutic approach.
  • Continued innovation in materials and device design is crucial for overcoming existing challenges.
  • Further research is needed to fully realize the potential of these advanced drug delivery platforms.