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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to

Dana M Gwinn1, Alex G Lee1, Marcela Briones-Martin-Del-Campo2

  • 1Division of Hematology and Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Division of Hematology and Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94158, USA.

Cancer Cell
|January 10, 2018
PubMed

Keywords:
ASNSATF4KEAP1KRASL-asparaginaseNRF2PI3Kasparagineglutaminesynthetic vulnerability

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