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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
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Related Experiment Video

Updated: Feb 15, 2026

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
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Budding Yeast Has a Minimal Endomembrane System.

Kasey J Day1, Jason C Casler1, Benjamin S Glick1

  • 1Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.

Developmental Cell
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Budding yeast possess a simplified endocytic pathway where the trans-Golgi network (TGN) functions as both early and recycling endosomes. This organization may represent an ancestral state of the endomembrane system.

Keywords:
Golgiendocytic pathwayendosomesmembrane traffictrans-Golgi networkyeast

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Yeast Genetics

Background:

  • The endomembrane system comprises secretory and endocytic pathways.
  • Mammalian cells have distinct early, late, and recycling endosomes.
  • Endocytic pathway organization in budding yeast remains unclear.

Purpose of the Study:

  • To elucidate the spatial and temporal organization of the yeast endocytic pathway.
  • To determine the roles of the trans-Golgi network (TGN) and prevacuolar endosome (PVE) in yeast endocytosis.

Main Methods:

  • Spatial and temporal analysis of yeast endosomal markers.
  • Tracking of endocytic cargoes within yeast cells.
  • Perturbation of transport dynamics from the TGN.

Main Results:

  • The yeast TGN acts as both an early and recycling endosome.
  • Yeast possesses a late endosome, also known as the prevacuolar endosome (PVE).
  • Endocytic cargo transiently localizes to the TGN before reaching the PVE.

Conclusions:

  • Budding yeast exhibits a simplified endocytic pathway lacking a distinct early endosome.
  • The yeast endocytic pathway organization may reflect the ancestral endomembrane system structure.