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The design of columns under centric load is a fundamental aspect of structural engineering and is critical for ensuring the stability and integrity of structures. Euler's and Secant's formulas are central to understanding and calculating the critical load and deformation behaviors of columns, providing a basis for safe and effective structural design.
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Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
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Related Experiment Video

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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: A STAT3-Centric View.

Enzo Calautti1, Lidia Avalle2, Valeria Poli3

  • 1Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy. vincenzo.calautti@unito.it.

International Journal of Molecular Sciences
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

Signal Transducer and Activator of Transcription (STAT)3 is crucial in psoriasis. Targeting the Janus kinase/STAT3 pathway offers new therapeutic options for inflammatory skin conditions.

Keywords:
Janus kinasesSTAT3Th17 cellsautoimmunitypsoriasisskin inflammation

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Area of Science:

  • Dermatology and immunology
  • Molecular biology
  • Inflammatory diseases

Background:

  • Signal Transducer and Activator of Transcription (STAT)3 is implicated in psoriasis pathogenesis.
  • STAT3 hyperactivation occurs in cells central to disease initiation and maintenance.
  • STAT3 mediates signals from key cytokines like Interleukin (IL)-23, IL-17, and IL-22.

Purpose of the Study:

  • To review the pathological features of psoriasis.
  • To establish the rationale for targeting the Janus kinase (JAK)/STAT3 axis in psoriasis treatment.
  • To explore alternative therapeutic strategies beyond current biologic agents.

Main Methods:

  • Review of existing literature on psoriasis pathology.
  • Analysis of the role of the JAK/STAT3 signaling pathway in inflammatory conditions.
  • Evaluation of therapeutic potential of targeting JAK family kinases and STAT3.

Main Results:

  • STAT3 is a central mediator in psoriatic disease development.
  • Targeting the JAK/STAT3 pathway presents a viable therapeutic strategy.
  • Small molecule inhibitors targeting JAKs offer potential advantages in administration and cost.

Conclusions:

  • The JAK/STAT3 pathway is a promising target for psoriasis treatment.
  • Targeting JAKs and STAT3 provides an alternative to monoclonal antibodies.
  • Oral or topical JAK inhibitors may offer a more accessible and cost-effective treatment option.