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Skeletal Muscle Gender Dimorphism from Proteomics
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Leptin/adiponectin ratio in overweight patients - gender differences.

K Selthofer-Relatić1,2, R Radić3, A Stupin4

  • 11 Department for Cardiovascular Disease, Osijek University Hospital, Osijek, Croatia.

Diabetes & Vascular Disease Research
|January 11, 2018
PubMed
Summary

The leptin/adiponectin ratio may indicate early atherosclerosis risk in overweight individuals. This ratio differs significantly between genders, correlating with metabolic factors in men and visceral obesity in women.

Keywords:
Adiponectingenderleptinleptin/adiponectin ratiooverweight

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Syndrome

Background:

  • Obesity-related atherosclerosis involves complex metabolic and neurohumoral pathways.
  • The leptin/adiponectin (L/A) ratio is a potential marker for atherosclerosis in obese populations.

Purpose of the Study:

  • To evaluate the significance of the L/A ratio in overweight individuals.
  • To examine the relationship between the L/A ratio and anthropometric/metabolic parameters.
  • To investigate gender differences in the L/A ratio and its associations.

Main Methods:

  • Study included 80 overweight, non-diabetic adult males and females.
  • Measurements included biochemical blood analysis, anthropometrics, and cardiovascular parameters.
  • Serum leptin and adiponectin levels were quantified using radioimmunoassay and ELISA, respectively.

Main Results:

  • Females exhibited a significantly higher L/A ratio compared to males (p < 0.001).
  • In males, the L/A ratio positively correlated with total cholesterol, LDL, and triglycerides.
  • In females, the L/A ratio correlated with waist circumference and waist-to-hip ratio, indicators of visceral obesity.

Conclusions:

  • The L/A ratio may serve as an early atherosclerotic risk marker in obesity.
  • Gender significantly influences pathophysiological changes and clinical manifestations.
  • Sex hormones likely play a crucial role in neurohumoral adipose tissue activity.