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Related Experiment Video

Updated: Feb 15, 2026

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A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis.

M Mohany1, N Ashton2, A H Harrath1

  • 11Zoology Department,College of Science,King Saud University,Riyadh,Kingdom of Saudi Arabia.

Journal of Developmental Origins of Health and Disease
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

Maternal Ramadan-type fasting (RTF) during pregnancy significantly impacts male offspring kidney development. Gestational fasting delays nephrogenesis and reduces nephron number, potentially due to increased kidney cell apoptosis.

Keywords:
apoptosisfastingnephrogenesispregnancy

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Area of Science:

  • Developmental Biology
  • Nephrology
  • Reproductive Biology

Background:

  • Maternal nutrition during pregnancy is crucial for fetal development.
  • Ramadan-type fasting (RTF) involves intermittent fasting periods.
  • The impact of RTF on offspring kidney development requires further investigation.

Purpose of the Study:

  • To investigate the effects of maternal RTF on pregnancy outcomes.
  • To examine kidney development and nephron number in male rat offspring exposed to maternal RTF.
  • To assess long-term renal structural changes in offspring.

Main Methods:

  • Pregnant rats underwent either ad libitum feeding (control) or 16-hour daily food/water restriction (RTF).
  • Kidney structure was analyzed during fetal life, at birth, and in adulthood.
  • Parameters assessed included maternal physiology, litter characteristics, and offspring kidney histology, nephron number, and apoptosis.

Main Results:

  • Maternal RTF led to reduced maternal body weight, food intake, and plasma glucose levels.
  • Offspring exhibited lower birth weights and delayed nephrogenesis, characterized by less differentiated glomeruli and increased kidney apoptosis.
  • Maternal fasting resulted in a significant reduction in nephron number (~31%) and altered glomerular and interstitial structures in adult offspring.

Conclusions:

  • Gestational maternal Ramadan-type fasting significantly impairs male offspring kidney development.
  • Delayed nephrogenesis and reduced nephron number are key consequences, potentially mediated by increased apoptosis.
  • These findings highlight the potential long-term renal health risks associated with maternal fasting during pregnancy.