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Updated: Feb 15, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
Published on: September 2, 2025
Optimizing Success and Avoiding Mishaps in the Most Difficult Image-guided Breast Biopsies.
Sughra Raza1, Sona A Chikarmane1, Eva C Gombos1
1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Early breast cancer detection is crucial for optimal outcomes. This review addresses challenging image-guided core needle biopsy scenarios, offering methods for safe and successful tissue diagnosis using stereotactic, ultrasound, and MRI guidance.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Breast cancer presents a growing global health challenge, necessitating early detection for improved patient outcomes.
- Accurate tissue diagnosis via biopsy is a critical component of early breast cancer detection.
- While typically straightforward, image-guided core needle biopsies can present unique challenges for even experienced practitioners.
Purpose of the Study:
- To review challenging scenarios encountered during image-guided breast biopsies.
- To present effective techniques for ensuring safe and successful biopsies in difficult cases.
- To provide guidance on biopsy procedures utilizing stereotactic, ultrasound, and MRI modalities.
Main Methods:
- Literature review of challenging breast biopsy cases.
- Discussion of established and novel techniques for image-guided biopsies.
- Focus on stereotactic, ultrasound, and MRI-guided approaches.
Main Results:
- Identification of common and uncommon challenging biopsy situations.
- Presentation of practical, evidence-based solutions for these challenges.
- Emphasis on maintaining safety and diagnostic accuracy.
Conclusions:
- Addressing difficult biopsy scenarios is essential for comprehensive breast cancer diagnosis.
- Standardized, expert-guided techniques improve biopsy success rates.
- Multimodality guidance (stereotactic, ultrasound, MRI) is key to overcoming biopsy challenges.
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