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Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery

Jose A Adams1, Peter Pastuszko2, Arkady Uryash1

  • 1Division of Neonatology and Department of Research, Mount Sinai Medical Center, Miami Beach, FL, United States.

Medical Hypotheses
|January 11, 2018
PubMed

Insights

Preconditioning with pGz demonstrates cardio and neuroprotective effects in piglets by upregulating key cellular pathways. This suggests pGz may be a valuable, non-invasive strategy for children undergoing surgery.

Area of Science:

  • Cardiovascular Science
  • Neuroscience
  • Pediatric Surgery

Background:

  • Deep Hypothermic Circulatory Arrest (DHCA) poses risks to cardiac and neurological function.
  • Identifying protective strategies is crucial for pediatric surgical interventions.

Purpose of the Study:

  • To investigate the cardio and neuroprotective effects of pGz preconditioning.
  • To analyze the molecular pathways involved in pGz's protective mechanisms.

Main Methods:

  • Assessed protein expression of eNOS, anti-apoptotic, and anti-inflammatory pathways in neonatal piglet brains.
  • Evaluated myocardial function following DHCA with pGz preconditioning.

Main Results:

  • pGz preconditioning upregulated protective pathways, including eNOS, anti-apoptotic, and anti-inflammatory markers.
  • Animal data confirmed significant cardio and neuroprotective roles for pGz.

Conclusions:

  • pGz exhibits both cardio and neuroprotective properties.
  • pGz represents a promising, non-invasive preconditioning strategy for pediatric surgical patients.

Keywords:
Cardiopulmonary bypassDeep Hypothermic Cardiac Arrest (DHCA)Endothelial nitric oxide synthase (eNOS)HypoxiaNeuroprotectionNitric oxidePediatric surgeryPreconditioningWhole Body Periodic Acceleration (pGz)

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