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Related Concept Videos

Elasticity01:12

Elasticity

5.0K
Elasticity is the ability of an object to withstand the effects of distortion and to return to its original size and shape once the forces causing deformation are removed. When an elastic material deforms under the action of an external force, it experiences internal resistance to the deformation. However, if no external force is applied, it returns to its original state.
The elasticity of an object can be described by a stress-strain curve, which represents the relationship between stress...
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Elasticity in Concrete01:20

Elasticity in Concrete

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Upon subjecting concrete to moderate or high uniaxial compressive or tensile stresses, the strain response is non-linear relative to the stress applied. As the stress is removed, the resulting stress-strain curve deviates from the original path traced during loading, creating a hysteresis loop, indicative of the concrete's non-linear and non-elastic properties. Typically, a material's modulus of elasticity, which is a measure of the material's stiffness, is inferred from the linear...
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Elastic Potential Energy01:01

Elastic Potential Energy

19.8K
Elastic potential energy is the energy stored as a result of the deformation of an elastic object, such as the stretching of a spring. An object is elastic if it returns to its original shape and size after being deformed. 
Potential energy is also associated with the elastic force exerted by an ideal spring. The work done by this force can be represented as a change in the elastic potential energy of the spring. Thus, the work done by a perfectly elastic spring, in one dimension, depends...
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Strain and Elastic Modulus01:15

Strain and Elastic Modulus

9.1K
The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
9.1K
Elastic Collisions: Introduction01:00

Elastic Collisions: Introduction

15.2K
An elastic collision is one that conserves both internal kinetic energy and momentum. Internal kinetic energy is the sum of the kinetic energies of the objects in a system. Truly elastic collisions can only be achieved with subatomic particles, such as electrons striking nuclei. Macroscopic collisions can be very nearly, but not quite, elastic, as some kinetic energy is always converted into other forms of energy such as heat transfer due to friction and sound. An example of a nearly...
15.2K
Elastic Collisions: Case Study01:15

Elastic Collisions: Case Study

20.7K
Elastic collision of a system demands conservation of both momentum and kinetic energy. To solve problems involving one-dimensional elastic collisions between two objects, the equations for conservation of momentum and conservation of internal kinetic energy can be used. For the two objects, the sum of momentum before the collision equals the total momentum after the collision. An elastic collision conserves internal kinetic energy, and so the sum of kinetic energies before the collision equals...
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Updated: Feb 15, 2026

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging
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Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Published on: June 21, 2011

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Nanoparticle elasticity directs tumor uptake.

Peng Guo1,2,3, Daxing Liu3,4, Kriti Subramanyam1,5,6

  • 1Vascular Biology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.

Nature Communications
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

Particle elasticity influences nanocarrier accumulation in tumors. Soft nanolipogels show enhanced cellular and tumor uptake, suggesting elasticity is key for efficient drug delivery.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • The mechanical properties of drug delivery systems, particularly elasticity, are poorly understood.
  • Measuring microscale mechanics and tuning rheology without altering chemistry has been a significant challenge.

Purpose of the Study:

  • To investigate the role of tunable elasticity in nanolipogels (NLGs) for drug delivery.
  • To evaluate the in vitro cellular uptake and in vivo tumor accumulation of NLGs with varying elasticity.

Main Methods:

  • Fabrication of nanolipogels (NLGs) with tunable elasticity using lipid bilayers and an alginate core.
  • Characterization of NLG elasticity using atomic force microscopy, determining Young's moduli.
  • Assessment of cellular uptake by neoplastic and non-neoplastic cells.
  • Evaluation of in vivo tumor and organ accumulation in an orthotopic breast tumor model.

Main Results:

  • NLG elasticity was tunable, with Young's moduli ranging from 45 ± 9 to 19,000 ± 5 kPa.
  • Softer NLGs (Young's modulus <1.6 MPa) demonstrated significantly higher uptake by both neoplastic and non-neoplastic cells compared to stiffer NLGs (>13.8 MPa).
  • In vivo studies showed preferential accumulation of soft NLGs in tumors, while elastic NLGs accumulated in the liver.

Conclusions:

  • Particle elasticity is a critical determinant of nanocarrier biodistribution and tumor targeting.
  • Tunable NLG elasticity can be leveraged to enhance drug delivery efficiency to tumors.
  • Elasticity represents a promising design parameter for optimizing nanomedicine delivery systems.