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Updated: Feb 15, 2026

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
Published on: May 4, 2011
Cerebral oxygenation during umbilical arterial blood sampling in very low birth weight neonates
Jonathan P Mintzer1, Catherine Messina2
1Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Stony Brook Children's Hospital, Stony Brook, NY, USA. jonathan.mintzer@stonybrookmedicine.edu.
Objective:
Umbilical arterial blood sampling (UABS) has been associated with cerebral oxygen saturation (CrSO2) decrements in very low birth weight (VLBW) neonates. We sought to determine patient- and UABS procedure-related factors contributing to this effect.
Study Design:
In this prospective cohort study, cerebral near-infrared spectroscopy was performed during UABS procedures in VLBW neonates. Analyses were conducted to determine subject- and procedure-related factors correlating with CrSO2 decrements.
Result:
Thirty subjects (mean (±SD) 27 ± 2 week GA and 1058 ± 279 g BW) underwent 84 UABS procedures between 5 and 183 postnatal hours. Six (20%) experienced CrSO2 decrements, less than previously reported. Subjects with CrSO2 decrements had earlier GA and lower BW, though these were not statistically significant differences. CrSO2 decrements occurred with lower pre- and post-UABS pulse oximetry (p = 0.004; p < 0.001), lower arterial oxygen partial pressure (p < 0.001), lower baseline CrSO2 (p = 0.01), and faster "priming" blood reinfusion (p = 0.03) and saline flush (p = 0.02).
Conclusion:
UABS procedures appear to be associated with CrSO2 decrements more commonly among VLBW neonates already experiencing disturbances in cerebral oxygen delivery-consumption balance. Shorter durations of UABS procedural components may contribute to CrSO2 decrements.
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