Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Energy-releasing Steps of Glycolysis01:28

Energy-releasing Steps of Glycolysis

147.3K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
147.3K
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

18
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
18
ATP Energy Storage and Release01:31

ATP Energy Storage and Release

14.7K
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
14.7K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.6K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.6K
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

16
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
16
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

459
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
459

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injectable chitosan-based hydrogel via in situ gelation modulates the inflammatory microenvironment and facilitates minimally invasive repair of peripheral nerve injury.

Materials today. Bio·2026
Same author

Highly bio-adapted hydrogels for tendon-bone interface regeneration: Natural healing inspiration, design strategies, and biomedical potential.

Bioactive materials·2026
Same author

Current state of bioceramic bone repair materials in immune regulation: a review.

Frontiers of medicine·2025
Same author

Machine Learning Prediction of Poor Flexion-Extension Outcome After Open Elbow Arthrolysis: Identifying Individual Predisposition Using Clinical and Laboratory Indicators.

Orthopaedic journal of sports medicine·2025
Same author

Hierarchical chirality of bone cement drives osteoinduction via integrin dependent signaling to accelerate critical bone defect regeneration.

Journal of nanobiotechnology·2025
Same author

The IL-33/ST2 Axis Promotes Traumatic Heterotopic Ossification by Driving Macrophage and Mast Cell-Mediated Inflammation via Autophagy Defects.

International journal of biological sciences·2025

Related Experiment Video

Updated: Feb 15, 2026

A Standardized Method for Measurement of Elbow Kinesthesia
07:56

A Standardized Method for Measurement of Elbow Kinesthesia

Published on: October 10, 2020

8.0K

Surgical release for tubercular elbow stiffness.

Yun Qian1,2, Qixin Han3, Wei Wang1,2

  • 1Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital.

Infection and Drug Resistance
|January 11, 2018
PubMed
Summary

Open arthrolysis with hinged external fixation effectively treats tuberculosis (TB) elbow stiffness, restoring significant range of motion and improving elbow function. This surgical approach offers a valuable solution for a rare complication of TB.

Keywords:
heterotopic ossificationhinged external fixationnon-traumaticopen arthrolysis

More Related Videos

Measuring the Bending Stiffness of Bacterial Cells Using an Optical Trap
05:45

Measuring the Bending Stiffness of Bacterial Cells Using an Optical Trap

Published on: April 26, 2010

12.5K
Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

20.8K

Related Experiment Videos

Last Updated: Feb 15, 2026

A Standardized Method for Measurement of Elbow Kinesthesia
07:56

A Standardized Method for Measurement of Elbow Kinesthesia

Published on: October 10, 2020

8.0K
Measuring the Bending Stiffness of Bacterial Cells Using an Optical Trap
05:45

Measuring the Bending Stiffness of Bacterial Cells Using an Optical Trap

Published on: April 26, 2010

12.5K
Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses
07:45

Simple Polyacrylamide-based Multiwell Stiffness Assay for the Study of Stiffness-dependent Cell Responses

Published on: March 25, 2015

20.8K

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Rheumatology

Background:

  • Tuberculosis (TB) remains a global health threat, with bone and joint involvement being common.
  • Elbow tuberculosis (TB) is a less frequent manifestation of extrapulmonary TB.
  • Limited reports exist on treating TB-induced elbow stiffness.

Purpose of the Study:

  • To evaluate the efficacy of open arthrolysis and hinged external fixation for treating tubercular elbow stiffness.
  • To assess the functional outcomes, including range of motion and performance scores, following surgical intervention.

Main Methods:

  • Retrospective analysis of six patients with tubercular elbow stiffness over seven years.
  • Surgical intervention involved open arthrolysis and hinged external fixation.
  • Outcomes measured by Mayo Elbow Performance Score (MEPS) and range of motion (ROM) pre- and post-operatively.

Main Results:

  • Significant improvements in active range of motion (ROM) were observed, with average flexion of 123.3°, extension of 11.7°, supination of 70°, and pronation of 68.3°.
  • The average Mayo Elbow Performance Score (MEPS) increased substantially to 92.5.
  • Three patients experienced complications, which were successfully managed with conservative treatment.

Conclusions:

  • Open arthrolysis combined with hinged external fixation is a beneficial treatment for non-traumatic elbow stiffness caused by tuberculosis (TB).
  • The procedure effectively restores elbow function and improves patient outcomes.