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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.5K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Acupuncture in a Rat Model of Asthma
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Microbiome and asthma.

Milena Sokolowska1,2, Remo Frei1,2, Nonhlanhla Lunjani1,2,3

  • 1Swiss Institute of Allergy and Asthma Research, University of Zürich, Obere Strasse 22, 7270 Davos, Switzerland.

Asthma Research and Practice
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

The microbiome influences mucosal immunity and asthma development. Analyzing gut and lung microbes may improve asthma diagnosis and lead to new bacterial therapies.

Keywords:
AsthmaBacteriaHistamineImmune toleranceMicrobiomeMucosal immune systemShort-chain fatty acids

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Area of Science:

  • Immunology
  • Microbiology
  • Genetics

Background:

  • The mucosal immune system constantly interacts with diverse microbes.
  • Host-microbe communication mechanisms reveal microbes' role in mucosal immunity.
  • Microbial dysbiosis is linked to asthma incidence and severity.

Purpose of the Study:

  • To explore the role of the microbiome in mucosal immunity and asthma.
  • To highlight the impact of microbial composition and activity on asthma endotyping and therapeutics.

Main Methods:

  • Review of molecular mechanisms mediating host-microbe communication.
  • Analysis of how the microbiome influences various immune cells (dendritic cells, epithelial cells, ILCs, T regulatory cells, effector lymphocytes, NKT cells, B cells).
  • Examination of the association between gut and lung microbial dysbiosis and asthma.

Main Results:

  • Novel molecular mechanisms mediate host-microbe communication, impacting mucosal immune responses.
  • Specific bacterial strains and metabolites play crucial roles in these interactions.
  • Microbial dysbiosis is increasingly associated with asthma's incidence and severity.

Conclusions:

  • Microbiome analysis can aid in accurate asthma endotyping.
  • Microbial composition and metabolic activity are key factors in asthma.
  • Future clinical studies should consider microbiome-influenced therapeutics, including novel bacterial-based treatments.