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Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus

Leila Tahernia1,2, Hosein Alimadadi3,4, Fatemeh Tahghighi2,3

  • 1Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Autoimmune Diseases
|January 11, 2018
PubMed

Insights

Nearly half of pediatric patients with systemic lupus erythematosus (SLE) experience hepatic involvement. Liver enzyme elevations were common, but not significantly correlated with other organ involvement in pediatric SLE.

Area of Science:

  • Pediatric Rheumatology
  • Hepatology
  • Systemic Lupus Erythematosus

Background:

  • Systemic lupus erythematosus (SLE) is a common rheumatologic condition in children.
  • Hepatic involvement is a frequent systemic manifestation of SLE.
  • Understanding the frequency and characteristics of liver involvement in pediatric SLE is crucial.

Purpose of the Study:

  • To determine the frequency and types of hepatic involvement in pediatric SLE patients.
  • To assess liver enzyme levels and their patterns in pediatric SLE.
  • To explore potential correlations between hepatic involvement and other clinical factors.

Main Methods:

  • An observational case-series study was conducted.
  • 138 pediatric SLE cases admitted between 2005 and 2014 were analyzed.
  • Frequency, type, and outcomes of hepatic involvement were assessed.

Main Results:

  • Hepatic involvement was observed in 48.55% of pediatric SLE patients.
  • Elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were detected in 8.7% and 5% respectively; both elevated in 34.7%.
  • Increased liver enzymes were more common in patients without gastrointestinal bleeding (P=0.007).

Conclusions:

  • Approximately half of pediatric SLE patients exhibit hepatic involvement.
  • No significant correlation was found between the involvement of various organs and abnormal liver enzyme levels.
Abstract

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