Related Experiment Video
Updated: Feb 15, 2026

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
Published on: May 8, 2017
Towards an MMP-2-activated molecular agent for cancer imaging
S Cowell1, L Carroll, I Lavdas
1Department of Chemistry, Imperial College London, London SW7 2AZ, UK. r.vilar@imperial.ac.uk.
None:
Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
More Related Videos
Related Concept Videos
Molecular Orbital Theory II
Molecular Orbital Theory I
Kinetic Molecular Theory: Molecular Velocities, Temperature, and Kinetic Energy
Molecular Models
Molecular Compounds: Formulas and Nomenclature
Subviral Agents

