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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Proteomics and transcriptomics in atrial fibrillation.

Marc Sühling1, Carmen Wolke1, Christian Scharf2

  • 1Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Ernst Moritz Arndt University Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany.

Herzschrittmachertherapie & Elektrophysiologie
|January 11, 2018
PubMed
Summary
This summary is machine-generated.

Atrial fibrillation (AF) is a common heart rhythm disorder. This review explores how transcriptomics and proteomics advance understanding of AF pathophysiology and atrial remodeling.

Keywords:
2D-DIGEMicroarray technologyRNA sequencingRapid-pacingTranscriptome

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Genomics

Background:

  • Atrial fibrillation (AF) is the most prevalent tachyarrhythmia, characterized by progressive atrial remodeling.
  • Molecular investigations have deepened the understanding of AF pathophysiology, yet complexity and patient heterogeneity remain challenges.
  • Omics technologies have significantly contributed to current knowledge of AF.

Purpose of the Study:

  • To review the role of transcriptomics and proteomics in understanding atrial fibrillation pathophysiology.
  • To highlight how omics data advances the study of atrial remodeling in AF.
  • To discuss the potential of integrative omics approaches for future AF research.

Main Methods:

  • Literature review focusing on transcriptomics studies in AF.
  • Literature review focusing on proteomics studies in AF.
  • Analysis of integrative approaches combining different omics data.

Main Results:

  • Transcriptomics provides insights into gene expression changes during atrial remodeling in AF.
  • Proteomics reveals alterations in protein profiles associated with AF pathophysiology.
  • Integrative omics approaches offer a more comprehensive view of AF mechanisms.

Conclusions:

  • Transcriptomics and proteomics are crucial for elucidating AF pathophysiology.
  • Advanced omics and integrative strategies promise to overcome limitations in AF research.
  • Further research utilizing these technologies will enhance understanding and treatment of AF.