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Updated: Feb 15, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
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Management of Statin Intolerance in 2018: Still More Questions Than Answers

Peter P Toth1,2, Angelo Maria Patti3, Rosaria Vincenza Giglio3

  • 1CGH Medical Center, Sterling, IL, USA.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
|January 11, 2018
PubMed

Insights

Statin intolerance, marked by side effects like muscle pain, can lead to patients stopping medication, increasing cardiovascular risk. Management includes dose changes, switching statins, or using alternative therapies when needed.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Statins are effective for cardiovascular disease prevention but can cause adverse events like myalgia and diabetes.
  • Patients often discontinue statin therapy due to perceived side effects, elevating cardiovascular event risk.

Purpose of the Study:

  • To define statin intolerance.
  • To outline clinical and therapeutic strategies for managing statin intolerance.
  • To explore emerging alternative therapies for cardiovascular disease management.

Main Methods:

  • This is a review article.
  • It synthesizes current literature on statin intolerance.
  • It discusses management strategies and alternative treatments.

Main Results:

  • Statin intolerance is a significant issue leading to treatment discontinuation.
  • Management strategies include dose adjustment, switching statins, or alternate-day regimens.
  • Non-statin drugs and nutraceuticals are options when all statins are poorly tolerated.

Conclusions:

  • Effective management of statin intolerance is crucial for cardiovascular risk reduction.
  • A range of strategies exists, from modifying statin therapy to exploring non-statin alternatives.
  • Further research into alternative therapies is warranted.

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