Phosphonate-functionalized poly(β-amino ester) macromers as potential biomaterials.
Ece Akyol1, Mirac Tatliyuz1, Fatma Demir Duman2
1Department of Chemistry, Bogazici University, Bebek, Istanbul, 34342, Turkey.
Journal of Biomedical Materials Research. Part A
|January 11, 2018
Summary
Novel phosphonate-functionalized poly(β-amino ester) (PBAE) gels were synthesized and show tunable biodegradability and enhanced cell attachment for biomaterial applications. These phosphorus-containing materials offer promising properties for tissue engineering and regenerative medicine.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Phosphorus-containing biomaterials are crucial for tissue engineering due to their biodegradability, hemocompatibility, and hydroxyapatite (HAP) interactions.
- Developing novel biomaterials with tailored properties is essential for advancing regenerative medicine.
Purpose of the Study:
- To synthesize novel phosphonate-functionalized poly(β-amino ester) (PBAE) macromers and their corresponding biodegradable gels.
- To investigate the biodegradability, cell attachment, and cytotoxicity of these novel phosphonate-functionalized PBAE gels.
Main Methods:
- Synthesis of phosphonate-functionalized PBAE macromers via aza-Michael addition without a catalyst.
- Photopolymerization of macromers to form biodegradable gels.
- Evaluation of gel degradation, SaOS-2 cell attachment, and cytotoxicity of degradation products.
Main Results:
- Phosphonate-functionalized PBAE gels exhibited tunable degradation rates based on acrylate choice and ratio.
- Gels demonstrated enhanced SaOS-2 cell attachment compared to non-phosphonated controls, with HDEDA-A1 showing optimal performance.
- Degradation products showed no significant cytotoxicity, except for HDDA-PA.
Conclusions:
- Novel phosphonate-functionalized PBAE gels offer tunable biodegradability and improved cell interaction.
- These materials show potential as advanced biomaterials for HAP-based tissue regeneration.
- The HDEDA-A1 based gel presents a promising candidate for biomaterial applications due to balanced hydrophilicity and cell support.
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