Related Experiment Video

Updated: Feb 15, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

5.6K

Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?

Ertan Sal1, Idil Yenicesu2, Nurullah Celik3

  • 1a Department of Pediatric Hematology , Batman State Hospital , Batman , Turkey.

Hematology (Amsterdam, Netherlands)
|January 11, 2018
PubMed

Insights

Hepcidin levels do not cause iron deficiency anemia in obese children, despite commonality of iron deficiency in this population. This study explored iron parameters, leptin, hepcidin, and adiponectin in obese children.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Hematology

Background:

  • Iron deficiency is prevalent in obese children, but the mechanisms remain unclear.
  • Obesity is associated with altered levels of hormones like leptin and adiponectin, which may influence iron metabolism.
  • Hepcidin, a key regulator of iron homeostasis, is implicated in various inflammatory conditions often comorbid with obesity.

Purpose of the Study:

  • To investigate the associations between iron parameters, leptin, hepcidin, and adiponectin levels in obese children.
  • To determine if hepcidin levels contribute to iron deficiency anemia in pediatric obesity.
  • To explore the relationship between obesity, inflammation, and iron status in children.

Main Methods:

  • A cross-sectional study involving 237 children (180 obese, 57 healthy controls) aged 5–18 years.
  • Comprehensive analysis of complete blood count, serum iron, iron-binding capacity, ferritin, leptin, hepcidin, and adiponectin.
  • Comparison of biochemical and hematological parameters between obese and control groups.

Main Results:

  • Obese children exhibited higher white blood cell count, platelet count, iron-binding capacity, C-reactive protein, leptin, and hepcidin.
  • Lower mean corpuscular volume, adiponectin, and transferrin saturation were observed in the obese group.
  • No significant differences in hemoglobin, serum ferritin, iron, or IL-6 levels were found between groups.

Conclusions:

  • Hepcidin levels do not appear to be a significant factor in the development of iron deficiency anemia in pediatric obesity.
  • The study highlights complex metabolic alterations in obese children, including dysregulation of iron-related hormones and inflammatory markers.
  • Further research is needed to elucidate the precise mechanisms linking obesity and iron status in children.
Abstract

Keywords:
Obesityhepcidiniron deficiencyleptin

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.4K
Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.6K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
Relationship Formation02:12

Relationship Formation

What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.3K
Ending Relationships01:28

Ending Relationships

The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
207
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship01:14

Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship

For drugs producing a quantal response, onset occurs when plasma concentration reaches a minimum effective level (Cmin). The drug's action duration depends on how long the plasma concentration remains above Cmin.Two primary factors influence this duration: dose size and the rate of drug removal from the action site. Both depend on the drug's redistribution to poorly perfused tissues and elimination processes. A larger dose promotes rapid onset and prolongs the effect's duration.Consider a...
24
Relationship Growth01:27

Relationship Growth

Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
232
Pharmacokinetic–Pharmacodynamic Relationship: Intensity of Dose-Effect Relationship01:23

Pharmacokinetic–Pharmacodynamic Relationship: Intensity of Dose-Effect Relationship

Pharmacodynamics explores the relationship between drug concentration and its effect. In a quantal response drug, the duration of action better correlates with drug concentration, while for graded effect drugs, the intensity of response is more relevant. This intensity depends on the dose, drug removal rate, and the region of the concentration–response curve.The concentration–response curve can be divided into three regions. Region 3 (80–100% maximum response) demonstrates...
21