Nanodiagnostics and Nanodelivery Applications in Genetic Alterations

Area of Science:

• Nanotechnology applications in healthcare
• Genomics and personalized medicine
• Biomarker discovery and assaying

Background:

• Hereditary diseases (HDs) encompass a spectrum of genetic disorders with varying incidences, including rare diseases (RDs).
• International research efforts are accelerating gene identification, prenatal diagnosis, and treatment development for HDs.
• Nanomedicine presents innovative solutions for diagnostics, drug delivery, and monitoring in HDs.

Purpose of the Study:

• To review recent advancements in nanotechnology for hereditary diseases.
• To highlight nanomedicine's potential in diagnostics, disease monitoring, and drug delivery for HDs.
• To discuss the role of nanotechnologies in understanding genetic alterations and developing novel therapies.

Main Methods:

• Review of current literature on nanotechnology applications in hereditary diseases.
• Analysis of nanodiagnostics for early and precise disease detection.
• Exploration of nanovectors for targeted drug delivery and gene therapy.
• Evaluation of artificial tissues for studying disease mechanisms and drug targets.

Main Results:

• Nanodiagnostics offer cost-effective, precise, and early disease detection, including for rare diseases.
• Nanovectors are emerging as a key approach for treating various diseases, including cancers and neurological disorders.
• Artificial tissues provide platforms for personalized research into pathogenic mechanisms and drug discovery.

Conclusions:

• Nanotechnology is a pivotal field for innovation in hereditary disease research and healthcare.
• Nanomethods facilitate genetic alteration identification and disease course monitoring.
• Nanodelivery systems and nanomatrix-based artificial tissues show promise for novel genetic therapies and understanding hereditary disorders.