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Confronting Penetration Threshold via Fluidic Terpenoid Nanovesicles.

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|January 11, 2018
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Summary

Invasomes, a type of deformable vesicle, show promise for enhanced topical delivery. Further research is needed to fully understand their dermatopharmacokinetics and long-term safety for drug delivery applications.

Keywords:
Invasomesdermal/topical targetingdermatopharmacokineticspilosebaceous targetingterpenes toxicitytopical delivery.

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Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Deformable nanovesicles like transfersomes and ethosomes are well-researched.
  • Invasomes, another class of deformable vesicles, have received less scientific attention.
  • This review focuses on advancing the understanding of invasomes for dermal and topical applications.

Purpose of the Study:

  • To provide an updated review of invasomal formulations for dermal and topical delivery.
  • To explore the effectiveness and permeation-enhancing capabilities of invasomes.
  • To identify research gaps and opportunities in invasome technology.

Main Methods:

  • A comprehensive literature search was conducted using the Scopus database.
  • The review focused on research articles detailing invasomal formulations and their applications.
  • Key aspects such as penetration mechanisms and delivery applications were analyzed.

Main Results:

  • While research reports on invasomes exist, patent citations are scarce.
  • Invasomes demonstrate potential in dental applications, photodynamic therapy, and pilosebaceous targeting.
  • Novel penetration enhancement techniques like massage and microneedles are emerging.
  • Most studies focus on temoporfin, indicating a need for research on other molecules.
  • Toxicity data for commonly used invasome terpenes are also highlighted.

Conclusions:

  • Invasomes offer an advantageous system for enhanced topical drug delivery.
  • Further investigation into dermatopharmacokinetics is required.
  • Long-term safety and toxicity assessments are crucial for clinical பயன்பாடு.