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Updated: Feb 15, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Sex-Based Differences in Discharge Disposition and Outcomes for ST-Segment Elevation Myocardial Infarction Patients
James R Langabeer1, Timothy D Henry2, Raymond Fowler3
11 School of Biomedical Informatics, University of Texas Health Science Center , Houston, Texas.
Women with ST-segment elevation myocardial infarction (STEMI) experience worse outcomes and are less likely to go home after treatment. These sex-based disparities persist even within a structured regional STEMI care system.
Area of Science:
- Cardiology
- Health Services Research
Background:
- Women with ST-segment elevation myocardial infarction (STEMI) have higher mortality rates than men.
- Biologic differences and care disparities are implicated, but their persistence in regional STEMI systems is unclear.
Purpose of the Study:
- To explore sex-related effects on outcomes within a large, regionalized STEMI system of care.
- Investigate if established sex-based disparities in STEMI care persist.
Main Methods:
- Analysis of data from the National Cardiovascular Data Registry (2010-2015) for 33 hospitals in the Dallas County, Texas region.
- Exploration of adjusted differences between women and men for discharge disposition, door-to-balloon time (D2B), total ischemic time (TIS), length of stay, and in-hospital mortality.
Main Results:
- Women experienced significantly longer door-to-balloon (58 vs. 54 min) and total ischemic times (206 vs. 178 min).
- Women had a longer median length of stay (0.45 days) and lower survival rates (OR: 0.63; 95% CI: 0.52-0.76).
- Women were less likely to be discharged home (88% vs. 92%).
Conclusions:
- Sex-based disparities in cardiovascular outcomes and discharge disposition persist in women with STEMI.
- These disparities are evident even within a modern, regionalized system of care with defined protocols.
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