Related Experiment Video

Updated: Feb 15, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

971

Genetics in the prevention and management of coronary artery disease

Robert Roberts1,2

  • 1Department of Medicine for University of Arizona College of Medicine-Phoenix.

Current Opinion in Cardiology
|January 11, 2018
PubMed

Insights

Over 90 genetic risk variants for coronary artery disease (CAD) have been identified. A genetic risk score (GRS) effectively stratifies CAD risk, offering a lifetime perspective for primary prevention.

Area of Science:

  • Cardiovascular Genetics
  • Genomic Medicine
  • Preventive Cardiology

Background:

  • Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
  • Conventional risk factors do not fully capture individual susceptibility to CAD.
  • Genetic predisposition plays a significant role in CAD development.

Purpose of the Study:

  • To review identified genetic risk variants for coronary artery disease (CAD).
  • To describe the application of genetic risk scores (GRS) in CAD risk stratification.
  • To highlight the potential of GRS in the primary prevention of CAD.

Main Methods:

  • Systematic review of genetic association studies identifying CAD risk variants.
  • Analysis of studies utilizing genetic risk scores (GRS) for risk stratification.
  • Evaluation of GRS performance against traditional risk factors.

Main Results:

  • Over 90 distinct genetic risk variants predisposing to CAD have been discovered.
  • The genetic risk burden for CAD is quantifiable through a genetic risk score (GRS).
  • GRS demonstrates superior efficacy in CAD risk stratification compared to conventional risk factors.

Conclusions:

  • Genetic risk variants provide valuable insights into CAD susceptibility.
  • The genetic risk score (GRS) offers a powerful tool for personalized CAD risk assessment.
  • GRS enables early and lifelong risk stratification, paving the way for a paradigm shift in CAD primary prevention.
Abstract

More Related Videos

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA13:10

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA

Published on: April 24, 2017

19.3K
Use of a Hanging Weight System for Coronary Artery Occlusion in Mice08:30

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Published on: April 19, 2011

22.1K

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
736
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
553
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
307
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
430
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
429