Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Accurate and superaccurate gene mapping.

K Lange, L Kunkel, J Aldridge

American Journal of Human Genetics

|September 1, 1985

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring the psychosocial implications of general population screening for paediatric type 1 diabetes in Europe: Protocol for a mixed-methods study.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

A standardised approach to the pathological dissection and reporting of pelvic exenteration specimens: Recommendations from the UK Pelvic Exenteration Network (UKPEN).

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026

Same author

Human factor in the use of automated insulin delivery systems: Real-world effects in children with type 1 diabetes after 2 years of use (AID-A study).

Diabetes research and clinical practice·2025

Same author

A very rare case of osseous involvement of the dens axis in a 52-year-old HIV positive patient as part of secondary syphilis.

Infection·2025

Same author

Scar endometriosis, a form of abdominal wall endometriosis-a neglected obstetrical complication?

Archives of gynecology and obstetrics·2024

Same author

ISPAD Position Statement on Type 1 Diabetes in Schools.

Hormone research in paediatrics·2024

Developing accurate gene mapping is crucial for cloning disease genes. This study quantifies the limits of the pedigree method and proposes a probe-based technique to detect submicroscopic deletions for improved gene localization.

Area of Science:

Genetics
Molecular Biology
Medical Research

Background:

Accurate gene mapping is essential for identifying disease-causing genes.
Classical gene mapping methods like pedigree analysis and cytogenetic aberrations have resolution limitations.

Purpose of the Study:

To quantify the resolution limits of the pedigree method for gene mapping.
To propose and evaluate a novel technique for gene localization using random probes to detect submicroscopic deletions.

Main Methods:

Quantitative analysis of the pedigree method's resolution limits.
Development and theoretical evaluation of a probe-based strategy for detecting submicroscopic deletions at disease loci.

Main Results:

Related Experiment Videos

The resolution limits of the pedigree method were quantitatively determined.

A probe-based approach can efficiently detect target submicroscopic deletions with relatively few probes.

Conclusions:

The pedigree method has inherent resolution limitations for gene mapping.
A probe-based strategy, guided by cytogenetic data and pedigree studies, offers a powerful approach for localizing disease genes by detecting submicroscopic deletions.