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Updated: Feb 15, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
A Retrospective Examination of Feline Leukemia Subgroup Characterization: Viral Interference Assays to Deep
Elliott S Chiu1, Edward A Hoover2, Sue VandeWoude3
1Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80524, USA. elliott.chiu@colostate.edu.
Abstract:
Feline leukemia virus (FeLV) was the first feline retrovirus discovered, and is associated with multiple fatal disease syndromes in cats, including lymphoma. The original research conducted on FeLV employed classical virological techniques. As methods have evolved to allow FeLV genetic characterization, investigators have continued to unravel the molecular pathology associated with this fascinating agent. In this review, we discuss how FeLV classification, transmission, and disease-inducing potential have been defined sequentially by viral interference assays, Sanger sequencing, PCR, and next-generation sequencing. In particular, we highlight the influences of endogenous FeLV and host genetics that represent FeLV research opportunities on the near horizon.
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