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Emerging Treatment Options in Atopic Dermatitis: Systemic Therapies
Uffe Nygaard1, Christian Vestergaard, Mette Deleuran
1Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.
Dermatology (Basel, Switzerland)
|January 11, 2018
Summary
New systemic therapies for atopic dermatitis (AD) target immune pathways. These novel drugs, focusing on specific cellular signals, offer potentially more effective and safer treatment options for patients with difficult-to-treat AD.
Area of Science:
- Immunology
- Dermatology
- Pharmacology
Background:
- Atopic dermatitis (AD) pathogenesis is complex, with varied clinical presentations and triggers.
- While most AD patients respond to current treatments, treatment failures necessitate new therapeutic strategies.
- Existing therapies often involve emollients combined with topical or systemic agents.
Purpose of the Study:
- To review systemic drugs in development for atopic dermatitis.
- To focus on novel therapies targeting immune pathways involved in AD pathogenesis.
- To identify emerging treatments based on clinical trial data.
Main Methods:
- Systematic review of systemic therapies for AD.
- Data sourced from clinicaltrials.gov database.
- Inclusion criteria: therapies with first received date between January 1, 2014, and May 31, 2017.
- Exclusion criteria: traditional Chinese medicine, herbal medicine, probiotics, histamine/leukotriene blockers, immuno-adsorption, or immunostimulants.
Main Results:
- Multiple novel systemic agents targeting specific immune pathways are in development for AD.
- These agents aim for precise modulation of cellular signals or pro-inflammatory pathways.
- The pipeline includes therapies designed to offer improved efficacy and safety profiles compared to existing treatments.
Conclusions:
- Novel systemic therapies targeting the immune response show promise for treating atopic dermatitis.
- These targeted approaches may provide more effective and less harmful treatment options for patients with treatment-resistant AD.
- The ongoing development of these pharmaceutical agents represents a significant advancement in AD management.
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