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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

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Published on: June 14, 2016

Cardiac hypertrophy, hypertrophic cardiomyopathy, and hyperparathyroidism--an association

C Symons, F Fortune, R A Greenbaum

    British Heart Journal
    |November 1, 1985
    PubMed

    Insights

    Primary hyperparathyroidism often causes left ventricular hypertrophy. Elevated parathyroid hormone, not high calcium, appears linked to this heart condition, suggesting further diagnostic testing.

    Area of Science:

    • Cardiology
    • Endocrinology
    • Medical Research

    Background:

    • Left ventricular hypertrophy (LVH) is frequently observed in primary hyperparathyroidism.
    • The specific role of parathyroid hormone (PTH) versus hypercalcemia in LVH development requires clarification.

    Purpose of the Study:

    • To investigate the association between parathyroid hormone levels and left ventricular hypertrophy in patients with primary hyperparathyroidism.
    • To differentiate the contribution of PTH from that of calcium in the pathogenesis of LVH.

    Main Methods:

    • Retrospective analysis of 18 patients with hypertrophic cardiomyopathy (HCM).
    • Measurement of serum parathyroid hormone and calcium concentrations.
    • Echocardiographic assessment of left ventricular structure.

    Main Results:

    • Five of 18 patients with HCM had elevated PTH and normal calcium.
    • No LVH was observed in six patients with hypercalcemia alone.
    • A correlation was found between elevated PTH and LVH spectrum.

    Conclusions:

    • Parathyroid hormone, rather than hypercalcemia, is associated with left ventricular hypertrophy.
    • Echocardiography is recommended for patients with elevated PTH.
    • PTH measurement is advised for patients with unexplained LVH, particularly HCM.

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