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Updated: Feb 15, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in
Ji-Young Lee1, Sanghoon Moon, Yun Kyoung Kim
1Center for Genome Science,Korea National Institute ofHealth,KCDC,Cheongju-si,Chungcheongbuk-do 363-951,Korea. jepark39@gmail.com.
Abstract:
Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability inMI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.
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