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Updated: Feb 15, 2026

Stimulation of Vascular Endothelial Cells Using Neutrophil Extracellular Traps in the Presence of Low-Density Lipoprotein
Published on: August 12, 2025
Vascular protection by high-density lipoprotein-associated sphingosine-1-phosphate
1Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
Abstract:
Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein (HDL). Findings from a growing number of studies further indicate that sphingosine-1-phosphate (S1P) mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protection against atherosclerosis and ischemia/reperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S1P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.
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