Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

296
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
296
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

601
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
601
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

268
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
268
Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

564
Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
564
One-Compartment Open Model: Urinary Excretion Data and Determination of k01:11

One-Compartment Open Model: Urinary Excretion Data and Determination of k

656
The one-compartment open model leverages urinary excretion data to estimate renal clearance, which gauges the kidney's capacity to expel a drug. This method offers several benefits, including directly measuring drug elimination and assessing the kidney's contribution to overall drug clearance. However, this approach has limitations. It assumes sole renal excretion of the drug, which is not true for all drugs. Accurate urinary excretion and plasma drug concentration measurement can also...
656
How Data are Classified: Categorical Data01:11

How Data are Classified: Categorical Data

45.5K
A variable, usually notated by capital letters such as X and Y, is a characteristic or measurement that can be determined for each member of a population. Data are the actual values of variables. They may be numbers, or they may be words. Datum is a single value.
Data are classified based on whether they are measurable or not. Categorical data cannot be measured; instead, it can be divided into categories. For example, if Y denotes a person's party affiliation, some examples of Y include...
45.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inference for Stationary Log-Gaussian Cox Point Processes using Bayesian Deep Learning: Application to Human Oral Microbiome Image Data.

Spatial statistics·2026
Same author

Digital twin for ocular hemodynamics: Combining physiology-based modeling and machine learning for personalized glaucoma care.

Mathematical biosciences and engineering : MBE·2026
Same author

Retinal Venous Vulnerability in Primary Open Angle Glaucoma: The Combined Effects of Intraocular Pressure and Blood Pressure with Application to the Thessaloniki Eye Study.

La matematica·2025
Same author

Inference for Log-Gaussian Cox Point Processes using Bayesian Deep Learning: Application to Human Oral Microbiome Image Data.

ArXiv·2025
Same author

Assessing predictability of environmental time series with statistical and machine learning models.

Environmetrics·2025
Same author

Energetic trade-offs in migration decision-making, reproductive effort and subsequent parental care in a long-distance migratory bird.

Proceedings. Biological sciences·2024
Same journal

Double Parasitism by Two Cuckoo Gentes in a Daurian Redstart Nest.

Ecology and evolution·2026
Same journal

Size and Ecology of a Giant <i>Pavona clavus</i> Coral Colony in the Kingdom of Tonga.

Ecology and evolution·2026
Same journal

How to Account for Past Selection When Maternal Effects Are Cascading.

Ecology and evolution·2026
Same journal

Light and Pollination Limitation Alter Patterns of Fitness and Phenotypic Selection in <i>Sagittaria trifolia</i> L.: Insights From Sequential Inflorescences.

Ecology and evolution·2026
Same journal

Teaching Macrosystems Ecology Concepts With a Collaborative, Adaptable Education Module.

Ecology and evolution·2026
Same journal

Instance of a Heteroplasmic Mitogenome in Alvinocaridid Shrimp <i>Mirocaris fortunata</i> (Martin & Christiansen 1995) Found at the Moytirra Deep-Sea High-Temperature Hydrothermal Vent Field.

Ecology and evolution·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.8K

A hierarchical spatiotemporal analog forecasting model for count data.

Patrick L McDermott1, Christopher K Wikle1, Joshua Millspaugh2

  • 1Department of Statistics University of Missouri Columbia MO USA.

Ecology and Evolution
|January 12, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a hierarchical analog model for forecasting, enhancing ecological predictions. The new Bayesian approach rigorously quantifies forecast uncertainty, improving reliability for environmental systems.

Keywords:
ecological forecastinghierarchical Bayesian modelsnonlinear forecastingwaterfowl settling patterns

More Related Videos

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling
06:55

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

8.6K
Versatile Technique to Produce a Hierarchical Design in Nanoporous Gold
05:28

Versatile Technique to Produce a Hierarchical Design in Nanoporous Gold

Published on: February 10, 2023

2.2K

Related Experiment Videos

Last Updated: Feb 15, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.8K
Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling
06:55

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

8.6K
Versatile Technique to Produce a Hierarchical Design in Nanoporous Gold
05:28

Versatile Technique to Produce a Hierarchical Design in Nanoporous Gold

Published on: February 10, 2023

2.2K

Area of Science:

  • Ecology
  • Environmental Science
  • Statistical Modeling

Background:

  • Analog forecasting is a nonlinear, mechanism-free method for predicting system behavior based on historical similar states.
  • Previous analog forecasting applications were empirical, lacking a formal statistical framework and rigorous uncertainty quantification.
  • Hierarchical statistical models offer a robust framework for complex data, including count observations.

Purpose of the Study:

  • To extend the model-based analog method into a fully hierarchical statistical framework.
  • To develop a Bayesian approach for rigorous uncertainty quantification in analog forecasts.
  • To apply the hierarchical analog model to forecast waterfowl settling patterns using breeding population survey data.

Main Methods:

  • Developed a hierarchical analog model incorporating Bayesian inference to handle count data.
  • Integrated sea surface temperature (SST) data from the Pacific Ocean to identify potential analogs.
  • Applied the model to a waterfowl breeding population survey dataset for forecasting settling patterns.

Main Results:

  • The hierarchical analog model successfully accommodated count observations within a formal statistical framework.
  • Bayesian methods provided rigorous quantification of forecast uncertainty.
  • The model demonstrated applicability in forecasting ecological patterns, specifically waterfowl settling.

Conclusions:

  • The hierarchical analog model provides a statistically rigorous and robust framework for analog forecasting.
  • This Bayesian approach enhances the reliability of ecological forecasts by quantifying uncertainty.
  • The method shows promise for application in various ecological and physical processes requiring robust predictions.