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Updated: Feb 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Desquamative interstitial pneumonia complicated by diffuse alveolar haemorrhage
Ayako Matsuo1, Nobuhiro Matsumoto1, Akiko Kitamura1
1Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine University of Miyazaki Miyazaki Japan.
This case study details a rare instance of desquamative interstitial pneumonia (DIP) complicated by diffuse alveolar hemorrhage (DAH). Prompt steroid therapy effectively treated the respiratory failure caused by influenza A/H3N2 virus infection.
Area of Science:
- Pulmonology
- Critical Care Medicine
Background:
- Desquamative interstitial pneumonia (DIP) is a rare lung disease.
- Diffuse alveolar hemorrhage (DAH) is a serious complication that can occur in patients with interstitial lung diseases.
Observation:
- A 56-year-old male with a history of DIP experienced severe acute respiratory failure.
- High-resolution computed tomography revealed diffuse ground glass opacity.
- Bronchoalveolar lavage fluid was bloody with haemosiderin-laden macrophages.
Findings:
- Influenza A/H3N2 virus infection was identified as the cause of DAH.
- The patient's respiratory failure and DIP progression were successfully managed with pulse steroid therapy and oral prednisolone.
Implications:
- This case highlights the importance of considering and treating viral infections in patients with DIP and DAH.
- Steroid therapy can be effective in managing acute respiratory failure secondary to DAH in the context of DIP.
- Early diagnosis and intervention are crucial for favorable outcomes in such rare presentations.
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