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Protective effects of salep against isoniazid liver toxicity in wistar rats
Hossein Kargar Jahromi1,2, Morteza Pourahmad1,3, Hassan Ali Abedi2
1Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Introduction:
Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.
Materials And Methods:
This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.
Results:
Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.
Conclusions:
Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.
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