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4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
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4D Multimodality Imaging of Citrobacter rodentium Infections in Mice

Published on: August 13, 2013

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Citrobacter rodentium Infection Model for the Analysis of Bacterial Pathogenesis and Mucosal Immunology

Catherine L Kennedy1, Elizabeth L Hartland2,3,4

  • 1Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|January 12, 2018
PubMed

Insights

Citrobacter rodentium is a mouse pathogen causing colon inflammation. This infection model is crucial for studying enteric diseases and immune responses, mimicking human inflammatory bowel diseases.

Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Citrobacter rodentium is a natural mouse pathogen causing transmissible colonic hyperplasia.
  • It induces colon thickening and inflammation, serving as a valuable research model.
  • The pathogen was first isolated from laboratory mouse colonies.

Purpose of the Study:

  • To investigate the pathogenesis of enteric disease using the C. rodentium model.
  • To understand the mucosal immune response to bacterial infection.
  • To explore parallels between C. rodentium infection and human inflammatory bowel diseases.

Main Methods:

  • Utilizing the C. rodentium infection model in mice.
  • Observing and analyzing colonic hyperplasia, inflammation, and dysbiosis.
  • Comparing disease features to human inflammatory bowel diseases.

Main Results:

  • The C. rodentium model effectively replicates key features of enteric disease.
  • It allows detailed study of the host's mucosal immune response.
  • Disease characteristics like inflammation and dysbiosis mirror aspects of human IBD.

Conclusions:

  • The C. rodentium infection model is essential for advancing our knowledge of enteric disease.
  • It provides critical insights into mucosal immunology and inflammatory processes.
  • This model aids research into inflammatory bowel diseases.
Keywords:
Bacterial cultureBacterial infectionCitrobacter rodentiumColitisImmune cell analysisMucosal immunity

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