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Cranio-vertebral pathology in Down syndrome.

J P Braakhekke, F J Gabreëls, W O Renier

    Clinical Neurology and Neurosurgery
    |January 1, 1985
    PubMed
    Summary

    Atlanto-axial dislocation is common in Down syndrome, but symptomatic cases are rare. Surgical intervention is recommended for symptomatic craniovertebral malformations in Down syndrome patients.

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    Area of Science:

    • Neurology
    • Genetics
    • Orthopedics

    Background:

    • Craniovertebral malformations, particularly atlanto-axial dislocation, are prevalent in individuals with Down syndrome.
    • Symptomatic presentations of these malformations in Down syndrome are infrequent.

    Observation:

    • Pyramidal signs are indicative of symptomatic atlanto-axial dislocation in Down syndrome.
    • The study highlights the diagnostic significance of pyramidal signs.

    Findings:

    • Surgical treatment is advised for symptomatic craniovertebral malformations.
    • Recommended surgical approaches include posterior fixation following traction-induced reduction or transoral odontoidectomy if reduction is unsuccessful.

    Implications:

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  • Early recognition of pyramidal signs is crucial for timely surgical management.
  • Effective surgical strategies can improve outcomes for Down syndrome patients with symptomatic atlanto-axial dislocation.