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Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F
Dileep Kumar Singh1, Ikyon Kim1
1College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University , 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.
Abstract:
Described herein is a novel synthetic approach to diptoindonesin G, a highly potent anticancer oligostilbenoid natural product, from pauciflorol F pentamethyl ether through a skeletal reorganization strategy where oxidative cleavage of the indanone ring system of pauciflorol F and sequential cyclization of the key intermediate allowed direct access to the target skeleton.
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