Related Experiment Video

Updated: Feb 15, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.0K

MicroRNAs in triple-negative breast cancer

M Koleckova, M Janikova, Z Kolar

    Neoplasma
    |January 12, 2018
    PubMed

    Insights

    MicroRNAs (miRs) are key regulators of gene expression and are implicated in triple-negative breast cancer (TNBC) development and treatment resistance. This review explores miRs as potential therapeutic targets and biomarkers for TNBC.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Genetics

    Background:

    • Triple-negative breast cancer (TNBC) presents a significant clinical challenge due to its aggressive nature and limited targeted therapies.
    • MicroRNAs (miRs) are crucial post-transcriptional regulators implicated in various cancers, including TNBC.
    • Dysregulated miRs can act as oncogenes or tumor suppressors, influencing carcinogenesis and treatment resistance.

    Purpose of the Study:

    • To review recent findings on microRNAs (miRs) in triple-negative breast cancer (TNBC).
    • To identify potential therapeutic targets influenced by miRs in TNBC.
    • To explore the role of circulating miRs as prognostic and predictive biomarkers in TNBC patients.

    Main Methods:

    • Literature review of recent publications on miRs and TNBC.
    • Analysis of data concerning miR dysregulation in TNBC.
    • Identification of novel therapeutic targets and biomarkers associated with miRs.

    Main Results:

    • MicroRNAs (miRs) play a critical role in TNBC pathogenesis, acting as oncogenes or tumor suppressors.
    • miR dysregulation is linked to resistance to conventional therapies like chemotherapy and radiotherapy.
    • Circulating miRs show promise as biomarkers for prognosis and predicting treatment response in TNBC.

    Conclusions:

    • MicroRNAs (miRs) represent promising therapeutic targets and biomarkers for triple-negative breast cancer (TNBC).
    • Targeting miRs could offer novel treatment strategies for TNBC.
    • Further research into miRs can improve diagnostic and prognostic capabilities for TNBC patients.
    Keywords:
    biomarkers therapeutic targets.microRNAtriple-negative breast cancer

    More Related Videos

    Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

    Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

    Published on: February 21, 2014

    20.7K
    Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System10:51

    Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

    Published on: April 23, 2021

    4.7K

    Related Concept Videos

    MicroRNAs01:22

    MicroRNAs

    MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
    24.3K
    MicroRNAs01:22

    MicroRNAs

    MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
    4.1K
    Scalar and Vector Triple Products01:06

    Scalar and Vector Triple Products

    Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
    The scalar triple product is the dot product of a vector with the cross product of two vectors....
    4.5K
    Negative Regulator Molecules01:23

    Negative Regulator Molecules

    Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
    38.6K
    Positive, Negative, and Zero Work00:58

    Positive, Negative, and Zero Work

    Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
    22.3K
    Negative and Cognitive Symptoms of Schizophrenia01:30

    Negative and Cognitive Symptoms of Schizophrenia

    Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
    Negative Symptoms
    Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
    653