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Are platelet volume indices related to mortality in hospitalized children on mechanical ventilation?

Sheng Ye1, Yanyi Zhang2, Chenmei Zhang1

  • 11 Pediatric Intensive Care Unit, 37066 The Children's Hospital, Zhejiang University School of Medicine , Hangzhou, China.

The Journal of International Medical Research
|January 12, 2018
PubMed

Insights

Platelet volume indices may indicate mortality risk in critically ill children on mechanical ventilation. While not directly associated on admission, trends over time showed differences between survivors and non-survivors.

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Intensive care research

Background:

  • Mechanical ventilation is critical for critically ill children.
  • Platelet indices are potential biomarkers for various conditions.
  • Understanding mortality predictors in this population is crucial.

Purpose of the Study:

  • To investigate the association between platelet volume indices and in-hospital mortality in pediatric patients requiring mechanical ventilation.
  • To identify risk factors for mortality in children on mechanical ventilation.

Main Methods:

  • Retrospective study of children (<16 years) on mechanical ventilation.
  • Comparison of admission parameters between survivors and non-survivors.
  • Analysis of dynamic platelet volume indices over 7 days and multivariate logistic regression.

Main Results:

  • Serum albumin, bilirubin, and lactic acid were associated with mortality in younger children (<3 years).
  • Procalcitonin and lactic acid were associated with mortality in older children (>3 years).
  • Platelet volume indices on admission were not independently linked to mortality, but trends over 1 week differed between survivors and non-survivors.

Conclusions:

  • Platelet volume indices may serve as potential indicators of mortality risk in critically ill children on mechanical ventilation.
  • Dynamic changes in platelet indices over time might be more informative than single admission measurements.

Keywords:
Mean platelet volumechildrenmechanical ventilationmortalityplatelet distribution width

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