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Fatigue in pediatric patients with familial Mediterranean fever

Semanur Özdel1, Z Birsin Özçakar1, Nilgün Cakar1

  • 1a Department of Pediatrics, Division of Pediatric Rheumatology , Ankara University School of Medicine , Ankara , Turkey.

Modern Rheumatology
|January 12, 2018
PubMed

Insights

Fatigue is a common issue for patients with Familial Mediterranean Fever (FMF), often overlooked. This study found FMF patients experience significant fatigue, similar to other chronic rheumatic diseases.

Area of Science:

  • Rheumatology
  • Pediatric Rheumatology
  • Internal Medicine

Background:

  • Familial Mediterranean Fever (FMF) presents with recurrent fever and serositis.
  • Fatigue is prevalent in pediatric rheumatic diseases but understudied in FMF.
  • Systematic evaluation of fatigue in FMF patients is lacking.

Purpose of the Study:

  • To assess fatigue levels in adolescent and young adult FMF patients.
  • To identify factors associated with fatigue in FMF.
  • To compare fatigue in FMF patients with other chronic rheumatic diseases and healthy controls.

Main Methods:

  • A cohort of 111 FMF patients (aged 10-21) completed the Checklist Individual Strength-20 (CIS-20) fatigue questionnaire.
  • Control groups included 54 patients with other chronic rheumatic diseases and 79 healthy children.
  • Statistical analysis compared fatigue scores between groups and explored associated factors.

Main Results:

  • FMF patients reported fatigue levels comparable to those with other chronic rheumatic diseases.
  • Both FMF and other chronic rheumatic disease groups exhibited significantly higher fatigue scores than healthy controls.
  • FMF patients with musculoskeletal complaints reported more severe subjective fatigue.

Conclusions:

  • Fatigue is a frequent and often unrecognized symptom in FMF patients.
  • FMF may present as a chronic condition with persistent symptoms between acute attacks.
  • Addressing fatigue is crucial for comprehensive FMF management.
Abstract

Keywords:
Childrenfamilial Mediterranean feverfatigue

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