Related Experiment Video
Updated: Feb 15, 2026

10:40
Measuring Neuromuscular Junction Functionality
Published on: August 6, 2017
18.7K
Expansile manubriotomy for ventral cervicothoracic junction disease
1Division of Minimally Invasive Neurosurgery, Medanta Institute of Neuroscience, Medanta The Medicity, Gurgaon, Haryana, India.
Neurology India
|January 12, 2018
Summary
Expansile manubriotomy offers a less invasive anterior surgical approach for cervicothoracic junction diseases. This technique provides excellent exposure for ventral spinal cord compression, with successful outcomes in most patients.
Area of Science:
- Neurosurgery
- Thoracic Surgery
- Spinal Surgery
Background:
- Anterior approaches to the cervicothoracic junction can cause significant morbidity.
- Ventral vertebral body disease in this region requires effective surgical access.
Purpose of the Study:
- To evaluate the feasibility and outcomes of expansile manubriotomy for anterior cervicothoracic junction disease.
- To assess the morbidity associated with this anterior surgical approach.
Main Methods:
- Expansile manubriotomy and corpectomy were performed on twelve patients with ventral cervicothoracic junction disease (T1-T3 levels).
- Surgical steps included midline manubrial division, lateral extension, and dissection to access the prevertebral fascia.
- Eleven patients underwent fusion, and one had an oblique corpectomy.
Main Results:
- The procedure was technically feasible and successfully completed in all patients.
- The approach provided adequate exposure for ventral disease affecting the T1-T3 vertebral bodies.
- One patient with comorbidities (diabetes, end-stage renal disease, epidural abscess) died postoperatively.
Conclusions:
- Expansile manubriotomy is a technically feasible, less invasive, and low-morbidity anterior approach for accessing ventral disease above the T4 level.
- This technique is a viable option for managing anteriorly located pathologies in the cervicothoracic spine.
Related Concept Videos
P-N junction
1.4K
A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
1.4K
The Neuromuscular Junction
19.7K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
19.7K
Anchoring Junctions
5.1K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
5.1K
Adherens Junctions
6.6K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
6.6K
Gap Junctions
9.8K
The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
9.8K
Gap Junctions
57.4K
Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
57.4K

