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Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor

Christopher Daly1, Xiaozhong Qian2, Carla Castanaro2

  • 1Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York, 10591, USA. christopher.daly@regeneron.com.

Scientific Reports
|January 12, 2018
PubMed
Summary

Angiopoietins (Ang1 and Ang2) bind to thrombomodulin (TM), an endothelial protein, inhibiting its role in blood coagulation. This discovery reveals a new function for angiopoietins in regulating hemostasis.

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