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Night-shift work and hematological cancers: a population based case-control study in three Nordic countries.
Madar Talibov1, Eero Pukkala, Jan Ivar Martinsen
1Department of Epidemiology, Faculty of Social Sciences, University of Tampere, Tampere, Finland. Mader.Talibov@gmail.com.
Scandinavian Journal of Work, Environment & Health
|January 12, 2018
Summary
This study found no significant link between night-shift work and hematological cancers. However, a slight, non-significant increase in leukemia risk was observed with high cumulative night work exposure.
Area of Science:
- Occupational Health
- Epidemiology
- Hematology
Background:
- Night-shift work is prevalent globally, raising concerns about potential health impacts.
- Previous research on night work and cancer risk, particularly hematological malignancies, has yielded mixed results.
- Understanding the association between occupational exposures and cancer is crucial for public health initiatives.
Purpose of the Study:
- To investigate the association between night-shift work and the risk of developing hematological cancers.
- To assess the risk of specific hematological cancers, including leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, and multiple myeloma.
- To evaluate the impact of cumulative night work exposure on cancer risk.
Main Methods:
- A large case-control study involving over 130,000 individuals diagnosed between 1961 and 2005 in Nordic countries.
- Cases of leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, and multiple myeloma were identified.
- Night-shift work exposure was assessed using the Nordic Occupational Cancer Study (NOCCA) job-exposure matrix (JEM), with matched controls.
Main Results:
- No overall significant association was found between night-shift work and hematological cancers.
- A small, non-significant increased risk for leukemia (OR 1.07) was observed, particularly for acute myeloid leukemia (OR 1.15) with high cumulative night work exposure.
- Night work exposure showed no association with lymphatic cancers or multiple myeloma.
Conclusions:
- The study does not support a link between night-shift work and an increased risk of hematological cancers.
- While a slight, non-significant trend was noted for leukemia, overall findings suggest no substantial association.
- Further research may be warranted to explore specific subgroups or exposure durations.
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