Related Experiment Video
Updated: Feb 15, 2026
14:25
Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
Published on: September 21, 2019
7.7K
Synthesis of 2-d-acrylamide
Alexey V Salin1, Rashid Z Musin2
1A.M. Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
Journal of Labelled Compounds & Radiopharmaceuticals
|January 12, 2018
Summary
Deuterated acrylamide (2-d-acrylamide) was synthesized using a two-step method. The process yielded highly pure 2-d-acrylamide with excellent isotopic enrichment, suitable for various applications.
Area of Science:
- Organic Chemistry
- Isotope Synthesis
Background:
- Acrylamide is a versatile monomer used in polymer synthesis.
- Deuterated compounds are crucial for mechanistic studies and as internal standards in analytical chemistry.
Purpose of the Study:
- To develop a reliable synthesis of deuterated acrylamide (2-d-acrylamide).
- To achieve high chemical purity and isotopic enrichment in the synthesized 2-d-acrylamide.
Main Methods:
- A two-step synthesis procedure was employed.
- The starting materials were acrylonitrile and deuterium oxide.
Main Results:
- 2-d-acrylamide was successfully synthesized.
- The product achieved 99.9% chemical purity.
- An isotopic enrichment of 98.4% was obtained.
Conclusions:
- The described method provides a robust route to high-purity 2-d-acrylamide.
- The synthesized 2-d-acrylamide is suitable for applications requiring isotopic labeling.
Keywords:
deuterium-labeled acrylamidedeuterium-labeled acrylonitrileelectron-deficient alkeneshydrationMore Related Videos
Related Concept Videos
01:15Dehydration Synthesis
150.6K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
150.6K
02:17Synthesis and Decomposition Reactions
38.4K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
38.4K
01:59Lagging Strand Synthesis
61.6K
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
61.6K
02:36Transfer RNA Synthesis
13.4K
One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
13.4K
01:13meta-Directing Deactivators: –NO2, –CN, –CHO, –CO2R, –COR, –CO2H
6.8K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.8K
02:53Ribosomal RNA Synthesis
14.9K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.9K