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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Microvascular involvement in systemic sclerosis and systemic lupus erythematosus.
Didem Saygin1, Kristin B Highland2, Adriano R Tonelli2
1Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Microcirculation (New York, N.Y. : 1994)
|January 12, 2018
Summary
Microvascular changes are key in systemic sclerosis (SSc) and systemic lupus erythematosus (SLE), impacting patient health. This review covers their clinical signs, biology, and assessment methods like capillaroscopy.
Area of Science:
- Rheumatology and immunology, focusing on systemic autoimmune diseases.
Background:
- Microvascular alterations are critical in the pathology of Systemic Sclerosis (SSc) and Systemic Lupus Erythematosus (SLE).
- These vascular changes significantly contribute to patient morbidity and mortality in SSc and SLE.
Purpose of the Study:
- To review the clinical features and underlying pathobiology of microvascular damage in SSc and SLE.
- To examine current methodologies for evaluating microvascular involvement in these conditions.
Main Methods:
- Literature review of studies on microvascular changes in SSc and SLE.
- Analysis of diagnostic and assessment tools including capillaroscopy, laser imaging, infrared thermography, and iontophoresis.
Main Results:
- Microvascular changes are a hallmark of SSc and SLE, influencing disease progression and outcomes.
- Various clinical tools are available for assessing microvascular integrity, aiding in diagnosis and patient management.
Conclusions:
- Understanding microvascular pathophysiology is crucial for managing SSc and SLE patients.
- Effective assessment tools are vital for timely diagnosis and monitoring of microvascular complications in SSc and SLE.
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