Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.4K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.4K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.5K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.5K
Master Transcription Regulators02:23

Master Transcription Regulators

7.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.9K
GTPases and their Regulation02:14

GTPases and their Regulation

9.9K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.9K
Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss and gain of motor protein function cause microtubule bundle damage in Drosophila axons.

Current biology : CB·2026
Same author

Maturation of GABAergic signalling times the opening of a critical period in Drosophila melanogaster.

Scientific reports·2025
Same author

Signal-strapping as a protein-sequence search method for the discovery of metalloproteins.

Nature communications·2025
Same author

Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period.

PLoS biology·2025
Same author

Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.

The Journal of cell biology·2025
Same author

How neurons maintain their axons long-term: an integrated view of axon biology and pathology.

Frontiers in neuroscience·2023

Related Experiment Video

Updated: Feb 15, 2026

ROS Live Cell Imaging During Neuronal Development
09:25

ROS Live Cell Imaging During Neuronal Development

Published on: February 9, 2021

4.9K

Regulation of neuronal development and function by ROS.

Matthew C W Oswald1, Nathan Garnham2, Sean T Sweeney2

  • 1Department of Zoology, University of Cambridge, UK.

FEBS Letters
|January 12, 2018
PubMed
Summary

Reactive oxygen species (ROS) are key signaling molecules in the nervous system, regulating neuronal development and function. Understanding their roles is crucial for addressing age-related neurological decline and diseases.

Keywords:
NADPH oxidaseaxoncytoskeletondendritenervous systemneuronal polaritypathfindingplasticityreactive oxygen speciessynapse

More Related Videos

In ovo Electroporation in Chick Midbrain for Studying Gene Function in Dopaminergic Neuron Development
08:57

In ovo Electroporation in Chick Midbrain for Studying Gene Function in Dopaminergic Neuron Development

Published on: August 3, 2012

12.0K
Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases
06:56

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases

Published on: September 6, 2024

829

Related Experiment Videos

Last Updated: Feb 15, 2026

ROS Live Cell Imaging During Neuronal Development
09:25

ROS Live Cell Imaging During Neuronal Development

Published on: February 9, 2021

4.9K
In ovo Electroporation in Chick Midbrain for Studying Gene Function in Dopaminergic Neuron Development
08:57

In ovo Electroporation in Chick Midbrain for Studying Gene Function in Dopaminergic Neuron Development

Published on: August 3, 2012

12.0K
Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases
06:56

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases

Published on: September 6, 2024

829

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Biochemistry

Background:

  • Reactive oxygen species (ROS) traditionally viewed as damaging agents in neurodegeneration.
  • Emerging evidence highlights ROS's physiological roles in normal nervous system function.
  • Limited understanding of ROS signaling in neuronal development and plasticity.

Purpose of the Study:

  • To elucidate the underappreciated signaling roles of ROS in the nervous system.
  • To explore how ROS regulate fundamental neuronal processes.
  • To connect ROS metabolism to age-related and disease-associated neurological changes.

Main Methods:

  • Review of recent scientific literature on ROS in neuroscience.
  • Analysis of studies investigating ROS in neuronal development (polarity, growth cones).
  • Examination of ROS involvement in synaptic function and network activity.

Main Results:

  • ROS actively regulate neuronal polarity and growth cone guidance.
  • ROS are critical for establishing and modulating synaptic transmission.
  • ROS contribute to the fine-tuning of neuronal network activity.
  • Evidence suggests ROS signaling is integral to neuronal plasticity.

Conclusions:

  • ROS are vital signaling molecules, not just destructive agents, in the healthy nervous system.
  • Dysregulation of ROS metabolism may underlie age-related and pathological neuronal network changes.
  • Further research into ROS buffering and metabolism is essential for understanding neurological aging and disease.