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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Feb 15, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Stabilisation in colorectal cancer.

Stavros Petrou1, Nikki Campbell2

  • 1A Health Economist at MEDTAP, London, UK.

International Journal of Palliative Nursing
|January 12, 2018
PubMed
Summary
This summary is machine-generated.

Chemotherapy can improve Quality of Life (QoL) for cancer patients by stabilizing their disease. Nurses acting as proxies found stabilization QoL benefits nearly as high as partial response, outweighing short-term toxicity costs.

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Area of Science:

  • Oncology
  • Health Economics
  • Patient-Reported Outcomes

Background:

  • Disease stabilization is a key treatment goal in cancer care.
  • Quality of Life (QoL) is a crucial outcome measure alongside clinical response.
  • Chemotherapy's impact on QoL, particularly with disease stabilization, requires further investigation.

Purpose of the Study:

  • To evaluate the Quality of Life (QoL) benefits associated with disease stabilization in cancer patients undergoing chemotherapy.
  • To compare the QoL utility scores of disease stabilization versus partial response.
  • To assess the overall impact of chemotherapy, including toxicity, on patient QoL.

Main Methods:

  • A utility study was conducted with 30 UK oncology nurses acting as proxies for cancer patients.
  • Nurses assessed health state values related to metastatic colorectal cancer treatment.
  • Utility scores were used to quantify QoL benefits of different treatment outcomes.

Main Results:

  • Nurses assigned a high utility score (0.95) to disease stabilization, comparable to partial response (1).
  • Chemotherapy, specifically irinotecan (CAMPTO®), shows efficacy in stabilizing or partially responding disease in over 50% of metastatic colorectal cancer patients.
  • Short-term side effects of chemotherapy were considered less significant than the long-term QoL benefits.

Conclusions:

  • Disease stabilization achieved through chemotherapy offers substantial Quality of Life (QoL) benefits for cancer patients.
  • Active management of chemotherapy-induced toxicity is essential to maximize QoL gains.
  • For patients achieving stabilization or response, QoL improvements are likely to exceed the temporary burden of treatment side effects.