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Published on: July 3, 2021
Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD
Naomi O Davis1, Jeffrey Bower2, Scott H Kollins1
1Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina, United States of America.
Insights
A new digital treatment showed promise for improving attention and working memory in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study suggests potential for digital interventions in managing ADHD-related cognitive deficits.
Area of Science:
- Neuroscience
- Psychiatry
- Digital Therapeutics
Background:
- Pharmacological and behavioral therapies have limited efficacy for neurocognitive impairments in Attention-Deficit/Hyperactivity Disorder (ADHD).
- Existing cognitive training programs demonstrate restricted effectiveness in addressing ADHD-related cognitive deficits.
- Novel digital interventions are needed to target specific cognitive processes implicated in ADHD.
Purpose of the Study:
- To assess the acceptability of a novel digital treatment for children with ADHD.
- To explore the preliminary outcomes of a digital intervention targeting cognitive functions in ADHD.
- To evaluate treatment satisfaction and cognitive improvements in a pediatric ADHD population.
Main Methods:
- A proof-of-concept study involving 40 children with ADHD and 40 controls.
- Participants completed a 28-day at-home digital treatment regimen.
- Neuropsychological assessments and treatment satisfaction measures were administered pre- and post-intervention.
Main Results:
- High adherence (84%) and strong intervention appeal were reported.
- Significant improvements in attention were observed in the ADHD group and a high-severity subgroup.
- Enhancements in spatial working memory were noted for the ADHD group and the high-severity subgroup.
Conclusions:
- The digital treatment shows preliminary efficacy in improving attention and working memory in children with ADHD.
- Findings support the potential of this digital approach for enhancing cognitive functions in pediatric ADHD.
- Further large-scale randomized controlled trials are warranted to confirm efficacy and functional impact.
Objective:
Pharmacological and behavioral therapies have limited impact on the distinct neurocognitive impairments associated with ADHD, and existing cognitive training programs have shown limited efficacy. This proof-of-concept study assessed treatment acceptability and explored outcomes for a novel digital treatment targeting cognitive processes implicated in ADHD.
Method:
Participants included 40 children with ADHD and 40 children without ADHD. Following psychiatric screening, ADHD ratings, and baseline neuropsychological measures, participants completed 28-days of at-home treatment. Neuropsychological assessment was repeated at end-of-study along with treatment satisfaction measures.
Results:
Eighty-four percent of treatment sessions were completed and ratings showed strong intervention appeal. Significant improvements were observed on a computerized attention task for the ADHD group and a highly impaired ADHD High Severity subgroup. There was no change for the non-ADHD group. Spatial working memory also improved for the ADHD group and the ADHD High Severity subgroup.
Conclusion:
Findings provide preliminary support that this treatment may improve attention, working memory, and inhibition in children with ADHD. Future research requires larger-scale randomized controlled trials that also evaluate treatment impact on functional impairments.
Trial Registration:
ClinicalTrials.gov NCT01943539.
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