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Related Experiment Video

Updated: Feb 15, 2026

Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function

Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function

Published on: August 25, 2022

Tet protein function during Drosophila development.

Fei Wang¹, Svetlana Minakhina¹, Hiep Tran¹

¹Rutgers University, Department of Molecular Biology, Waksman Institute, Piscataway, NJ United States of America.

|January 12, 2018

Summary

This summary is machine-generated.

The Ten-eleven translocation (Tet) protein modifies RNA, and its function in Drosophila development is crucial for neuronal and muscle tissues. Loss of Tet function leads to developmental defects and lethality.

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Area of Science:

Epigenetics
Molecular Biology
Developmental Biology

Background:

Ten-eleven translocation (Tet) proteins are known DNA hydroxymethylases in vertebrates.
Recent studies indicate Tet proteins also hydroxylate 5-methylcytosine in RNA, forming 5-hydroxymethylcytosine (5hmrC).
The biological function of 5hmrC in RNA remains largely unknown.

Purpose of the Study:

To characterize the temporal and spatial expression of Tet in Drosophila.
To investigate the requirement of Tet during Drosophila development.
To elucidate the biological function of 5hmrC using Drosophila as a model.

Main Methods:

Analysis of Tet gene expression patterns throughout Drosophila development.
Generation of Tet loss-of-function and knockdown Drosophila models.
Assessment of developmental phenotypes, including viability, locomotion, and circadian rhythms.
Investigation of Tet function in ovarian morphogenesis.

Main Results:

Tet is essential for Drosophila viability, with complete loss-of-function leading to late pupal lethality.
Tet is highly expressed in neuronal tissues and moderately in muscle precursors.
Depletion of Tet in muscle precursors causes locomotion defects and pupal lethality.
Tet knockdown in neurons affects larval locomotion and adult circadian rhythms.
Tet plays a role in ovarian morphogenesis.

Conclusions:

Tet is vital for Drosophila development, impacting neuronal function, muscle development, and ovarian morphogenesis.
The study provides insights into the biological roles of Tet and RNA hydroxymethylation.
Findings may help understand vertebrate neuronal and muscle phenotypes.