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Related Experiment Video

Updated: Feb 15, 2026

PuraMatrix Encapsulation of Cancer Cells

PuraMatrix Encapsulation of Cancer Cells

Published on: December 17, 2009

A Transformable Chimeric Peptide for Cell Encapsulation to Overcome Multidrug Resistance.

Chi Zhang¹, Li-Han Liu¹, Wen-Xiu Qiu¹

¹Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan, 430072, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)

|January 12, 2018

Summary

A novel chimeric peptide self-assembles to overcome multidrug resistance (MDR) in chemotherapy. This peptide encapsulates cancer cells, enhancing drug retention and reversing MDR by transforming its nanostructure.

Keywords:

cell encapsulation chemotherapy membrane targetting multidrug resistance self-assembly

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Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapy

Background:

Multidrug resistance (MDR) is a major challenge in cancer chemotherapy, largely driven by P-glycoprotein (P-gp)-mediated drug efflux.
Developing strategies to overcome MDR is crucial for improving treatment efficacy.

Purpose of the Study:

To design a transformable chimeric peptide capable of targeting and self-assembling on cell membranes to overcome tumor MDR.
To encapsulate therapeutic agents and enhance their retention within drug-resistant cancer cells.

Main Methods:

A chimeric peptide (CTGP) was synthesized with cell membrane-targeting and cathepsin B-responsive elements.
CTGP self-assembled into nanomicelles encapsulating doxorubicin (DOX) to form CTGP@DOX.
Morphological transformation from nanoparticles to nanofibers was induced by cathepsin B cleavage, facilitating cell encapsulation and drug retention.

Main Results:

CTGP@DOX demonstrated efficient cell membrane targeting and encapsulation of drug-resistant MCF-7R cells.
The peptide underwent a significant morphological transformation upon cathepsin B cleavage, leading to enhanced drug retention.
CTGP@DOX achieved a 45-fold increase in drug retention and a 49-fold enhancement in anti-MDR activity compared to free DOX.

Conclusions:

The designed chimeric peptide effectively reverses tumor MDR by encapsulating cells and altering its nanostructure.
This morphology transformation strategy offers a promising new approach for enhancing chemotherapy efficacy in resistant tumors.